Article
Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans.
Diabetes - 1 Apr 2008
Black Mary Helen, Fingerlin Tasha E, Allayee Hooman, Zhang Weiming, Xiang Anny H, Trigo Enrique, Hartiala Jaana, Lehtinen Allison B, Haffner Steven M, Bergman Richard N, McEachin Richard C, Kjos Siri L, Lawrence Jean M, Buchanan Thomas A, Watanabe Richard M
Abstract excerpt
OBJECTIVE: We hypothesized that interaction between PPARG2 Pro12Ala and variants in the promoter region of HNF4A are associated with type 2 diabetes-related quantitative traits in Mexican-American families of a proband with previous gestational diabetes. RESEARCH DESIGN AND METHODS: The BetaGene project genotyped PPARG2 Pro12Ala and nine HNF4A single nucleotide polymorphisms (SNPs) in 473 individuals in 89...
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