E2Fs link the control of G1/S and G2/M transcription.

doi:10.1038/sj.emboj.7600459

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Article

E2Fs link the control of G1/S and G2/M transcription.

The EMBO journal - 24 Nov 2004

Zhu Wencheng, Giangrande Paloma H, Nevins Joseph R

Abstract excerpt

Previous work has provided evidence for E2F-dependent transcription control of both G1/S- and G2/M-regulated genes. Analysis of the G2-regulated cdc2 and cyclin B1 genes reveals the presence of both positive- and negative-acting E2F promoter elements. Additional elements provide both positive (CCAAT and Myb) and negative (CHR) control. Chromatin immunoprecipitation assays identify multiple interactions of E2F...

Topics

Animals
CDC2 Protein Kinase
Cell Cycle
Cell Cycle Proteins
Cells, Cultured
Chromatin Immunoprecipitation
Cyclin B
Cyclin B1
DNA-Binding Proteins
E2F Transcription Factors
E2F1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

E2F3 Transcription Factor

G1 Phase

G2 Phase

Gene Expression Regulation

Mutation

Promoter Regions, Genetic

RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 15510213
DOI: 10.1038/sj.emboj.7600459
PMCID: PMC533046

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