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Article

E2Fs link the control of G1/S and G2/M transcription.

The EMBO journal - 24 Nov 2004

Zhu Wencheng, Giangrande Paloma H, Nevins Joseph R

Abstract excerpt

Previous work has provided evidence for E2F-dependent transcription control of both G1/S- and G2/M-regulated genes. Analysis of the G2-regulated cdc2 and cyclin B1 genes reveals the presence of both positive- and negative-acting E2F promoter elements. Additional elements provide both positive (CCAAT and Myb) and negative (CHR) control. Chromatin immunoprecipitation assays identify multiple interactions of E2F...

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Identifiers

PMID: 15510213
DOI: 10.1038/sj.emboj.7600459
PMCID: PMC533046

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