Article
Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML.
Blood - 5 Jan 2012
Treppendahl Marianne Bach, Qiu Xiangning, Søgaard Alexandra, Yang Xiaojing, Nandrup-Bus Cecilie, Hother Christoffer, Andersen Mette Klarskov, Kjeldsen Lars, Möllgård Lars, Möllgaard Lars, Hellström-Lindberg Eva, Jendholm Johan, Porse Bo T, Jones Peter A, Liang Gangning, Grønbæk Kirsten
Abstract excerpt
Deletions of chromosome 5q are associated with poor outcomes in acute myeloid leukemia (AML) suggesting the presence of tumor suppressor(s) at the locus. However, definitive identification of putative tumor suppressor genes remains controversial. Here we show that a 106-nucleotide noncoding RNA vault RNA2-1 (vtRNA2-1), previously misannotated as miR886, could potentially play a role in the biology and prognosis...
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