Article
Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations.
Genome research - 1 Apr 2018
Shah Maitri Y, Ferracin Manuela, Pileczki Valentina, Chen Baoqing, Redis Roxana, Fabris Linda, Zhang Xinna, Ivan Cristina, Shimizu Masayoshi, Rodriguez-Aguayo Cristian, Dragomir Mihnea, Van Roosbroeck Katrien, Almeida Maria Ines, Ciccone Maria, Nedelcu Daniela, Cortez Maria Angelica, Manshouri Taghi, Calin Steliana, Muftuoglu Muharrem, Banerjee Pinaki P, Badiwi Mustafa H, Parker-Thornburg Jan, Multani Asha, Welsh James William, Estecio Marcos Roberto, Ling Hui, Tomuleasa Ciprian, Dima Delia, Yang Hui, Alvarez Hector, You M James, Radovich Milan, Shpall Elizabeth, Fabbri Muller, Rezvani Katy, Girnita Leonard, Berindan-Neagoe Ioana, Maitra Anirban, Verstovsek Srdan, Fodde Riccardo, Bueso-Ramos Carlos, Gagea Mihai, Manero Guillermo Garcia, Calin George A
Abstract excerpt
The cancer-risk-associated rs6983267 single nucleotide polymorphism (SNP) and the accompanying long noncoding RNA CCAT2 in the highly amplified 8q24.21 region have been implicated in cancer predisposition, although causality has not been established. Here, using allele-specific CCAT2 transgenic mice, we demonstrate that CCAT2 overexpression leads to spontaneous myeloid malignancies. We further identified that...
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