Article
Association between two polymorphisms of the bone morpho-genetic protein-2 gene with genetic susceptibility to ossification of the posterior longitudinal ligament of the cervical spine and its severity.
Chinese medical journal - 20 Sept 2008
Wang Hao, Yang Zhao-hui, Liu Dong-mei, Wang Ling, Meng Xiang-long, Tian Bao-peng
Abstract excerpt
BACKGROUND: Ossification of the posterior longitudinal ligament (OPLL) has a strong genetic background. Previous studies have shown that bone morphogenetic protein-2 (BMP2) and BMP2 mRNA are expressed in ossifying matrix and chondrocytes adjacent to cartilaginous areas of OPLL tissues and mesenchymal cells with fibroblastic features in the immediate vicinity of the cartilaginous areas. It is suggested that BMP2...
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