Article
A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine.
Human genetics - 1 Jul 2006
Horikoshi Taizo, Maeda Koichi, Kawaguchi Yoshiharu, Chiba Kazuhiro, Mori Kanji, Koshizuka Yu, Hirabayashi Shigeru, Sugimori Kazuhito, Matsumoto Morio, Kawaguchi Hiroshi, Takahashi Makoto, Inoue Hisashi, Kimura Tomoatsu, Matsusue Yoshitaka, Inoue Itsuro, Baba Hisatoshi, Nakamura Kozo, Ikegawa Shiro
Abstract excerpt
Research to date has identified several genes that are implicated in the etiology of ossification of the posterior longitudinal ligament of the spine (OPLL); however, their pathogenetic relevance remains obscure. The aim of this study is to identify susceptibility genes for OPLL through a large-scale case-control association study and to re-examine previously reported associations. A total of 109 single...
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