Article
Phenotypic assay of a hepatitis B virus strain carrying an rtS246T variant using a new strategy.
Journal of medical virology - 1 Jan 2012
Hu Jie-li, Cui Jing, Guo Jin-jun, Zhang Wen-lu, Cai Xue-fei, Yuan Zuo-wei, Li Qing-ling, Deng Xiao-yan, Zeng Ai-zhong, Hu Yuan, Tang Ni, Huang Ai-long
Abstract excerpt
Phenotypic assays of hepatitis B virus (HBV) play an important role in research related to the problem of drug resistance that emerges during long-term nucleot(s)ide therapy in patients with chronic hepatitis B. Most of the phenotypic assay systems that are available currently rely on the transfection of recombinant replication-competent HBV DNA into hepatoma cell lines. Cloning clinical HBV isolates using...
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