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Article

Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.

Journal of hepatology - 1 Aug 2017

Shirvani-Dastgerdi Elham, Winer Benjamin Y, Celià-Terrassa Toni, Kang Yibin, Tabernero David, Yagmur Eray, Rodríguez-Frías Francisco, Gregori Josep, Luedde Tom, Trautwein Christian, Ploss Alexander, Tacke Frank

Abstract excerpt

BACKGROUND & AIMS: Patients chronically infected with the hepatitis B virus (HBV) and receiving long-term treatment with nucleoside or nucleotide analogues are at risk of selecting HBV strains with complex mutational patterns. We herein report two cases of HBV-infected patients with insufficient viral suppression, despite dual antiviral therapy with entecavir (ETV) and tenofovir (TDF). One patient died from...

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Identifiers

PMID: 28392234
DOI: 10.1016/j.jhep.2017.03.027
PMCID: PMC6016549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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