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Article

Evidence that polymorphisms in detoxification genes modulate the susceptibility for sporadic medullary thyroid carcinoma.

European journal of endocrinology - 1 Feb 2012

Barbieri R B, Bufalo N E, Secolin R, Silva A C N, Assumpção L V M, Maciel R M B, Cerutti J M, Ward L S

Abstract excerpt

AIM: Polymorphic low-penetrance genes have been consistently associated with the susceptibility to a series of human tumors, including differentiated thyroid cancer. METHODS: To determine their role in medullary thyroid cancer (MTC), we used TaqMan SNP method to genotype 47 sporadic MTC (s-MTC) and a control group of 578 healthy individuals for CYP1A2*F, CYP1A1m1, GSTP1, NAT2 and 72TP53. A logistic regression...

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Source

Identifiers

PMID: 22048975
DOI: 10.1530/EJE-11-0843

Genes

NAT2
GSTP1

Provenance

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