Article
Common genetic variants in metabolism and detoxification pathways and the risk of papillary thyroid cancer.
Endocrine-related cancer - 1 Jun 2012
Aschebrook-Kilfoy Briseis, Neta Gila, Brenner Alina V, Hutchinson Amy, Pfeiffer Ruth M, Sturgis Erich M, Xu Li, Wheeler William, Doody Michele M, Chanock Stephen J, Sigurdson Alice J
Abstract excerpt
Relationships are unclear between polymorphisms in genes involved in metabolism and detoxification of various chemicals and papillary thyroid cancer (PTC) risk as well as their potential modification by alcohol or tobacco intake. We evaluated associations between 1647 tagging single nucleotide polymorphisms (SNPs) in 132 candidate genes/regions involved in metabolism of exogenous and endogenous compounds (Phase...
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