Article
Glucocorticoid receptor polymorphism BclI with increased glucocorticoid sensitivity has a positive influence on quality of life in endogenous Cushing's syndrome in remission.
European journal of endocrinology - 5 Apr 2023
Feldkamp Lara, Müller Lisa, Deutschbein Timo, Detomas Mario, Hahner Stefanie, Strasburger Christian J, Künzel Heike, Oßwald Andrea, Braun Leah, Rubinstein German, Reincke Martin, Quinkler Marcus, Kienitz Tina
Abstract excerpt
CONTEXT: Patients with endogenous Cushing's syndrome (CS) may suffer from a wide range of neuropsychiatric symptoms leading to impaired quality of life (QoL). OBJECTIVE: Glucocorticoid receptor (GR) polymorphisms are associated with increased (BclI and N363S) or decreased (A3669G and ER22/23EK) GR sensitivity. HYPOTHESIS: GR genotypes may modulate and affect QoL and recovery after remission differently via GR...
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