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Article

SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Wen Yanan, Miyashita Akinori, Kitamura Nobutaka, Tsukie Tamao, Saito Yuko, Hatsuta Hiroyuki, Murayama Shigeo, Kakita Akiyoshi, Takahashi Hitoshi, Akatsu Hiroyasu, Yamamoto Takayuki, Kosaka Kenji, Yamaguchi Haruyasu, Akazawa Kohei, Ihara Yasuo, Kuwano Ryozo

Abstract excerpt

SORL1 was shown to be genetically associated with late-onset Alzheimer's disease (LOAD) in a large-scale genome-wide association study (GWAS) involving clinically verified subjects. Here, we attempted to replicate the association of SORL1 in Japanese neuropathologically characterized brain donor subjects (LOAD, 213; control, 370) through a single-nucleotide polymorphism (SNP)-based genetic study involving 19...

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Source

Identifiers

PMID: 23455993
DOI: 10.3233/JAD-122395

Genes

SORL1
APOE

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