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Article

Tubulin-based Structure-affinity Relationships for Antimitotic Vinca Alkaloids

1 Mar 2012

Abstract excerpt

The Vinca alkaloids are a group of widely used anticancer drugs, originally extracted from the Madagascar periwinkle, that disrupt microtubule dynamics in mammalian cells by interfering with proper assembly of α,β-tubulin heterodimers. They favor curved tubulin assemblies that destabilize microtubules and induce formation of spiral aggregates. Their binding energy profiles have been characterized by means of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22044006
DOI: 10.2174/187152012800228841

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