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Systematic profiling of Taxol resistance and sensitivity to tubulin missence mutations at molecular and cellular levels.

Chemical biology & drug design - 1 Apr 2024

Zhou Lihua, Ding Xi, Cao Jingjing, Feng Yu, Gu Yuqin, Liu Ling, Chen Rong, Gao Dongyun, Chen Xiaoling

Abstract excerpt

Taxol (paclitaxel) is the first approved microtubule-stabilizing agent (MSA) by binding stoichiometrically to tubulin, which is considered to be one of the most significant advances in first-line chemotherapy against diverse tumors. However, a large number of residue missence mutations harboring in the tubulin have been observed to cause acquired drug resistance, largely limiting the clinical application of Taxol...

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PMID: 38570322
DOI: 10.1111/cbdd.14513

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