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Article

Potent Human Telomerase Inhibitors: Molecular Dynamic Simulations, Multiple Pharmacophore-Based Virtual Screening, and Biochemical Assays

3 Nov 2015

Abstract excerpt

Telomere maintenance is a universal cancer hallmark, and small molecules that disrupt telomere maintenance generally have anticancer properties. Since the vast majority of cancer cells utilize telomerase activity for telomere maintenance, the enzyme has been considered as an anticancer drug target. Recently, rational design of telomerase inhibitors was made possible by the determination of high resolution...

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Share to Advanced biosensing and bioanalysis techniques
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

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PMID: 26529120
DOI: 10.1021/acs.jcim.5b00336

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