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Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex

1 May 2019

Abstract excerpt

Trastuzumab and pertuzumab are monoclonal antibodies that bind to distinct subdomains of the extracellular domain of human epidermal growth factor receptor 2 (HER2). Adding these monoclonal antibodies to the treatment regimen of HER2-positive breast cancer has changed the paradigm for treatment in that form of cancer. Synergistic activity has been observed with the combination of these two antibodies leading to...

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PMID: 31042744
DOI: 10.1371/journal.pone.0216095

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