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Article

Oncogenic β-tubulin mutations disrupt nucleotide-dependent allostery and free energy landscape of tubulin dimer.

Computers in biology and medicine - 1 Mar 2026

Fazil Thasni, Suresh Sharanya C, Lavoori Ravindar, Natarajan Kathiresan

Abstract excerpt

Dynamic instability of microtubules arises from nucleotide-dependent conformational changes within the tubulin dimers; however, little is known about the molecular mechanisms linking specific mutations to microtubule dysfunction. Here, we combined molecular-dynamics simulations with multi-parametric analysis to investigate wild-type and four lung cancer-associated β-tubulin mutations: Q134L, D177H, G269S, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41633276
DOI: 10.1016/j.compbiomed.2026.111512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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