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Article

Understanding the basis of drug resistance of the mutants of αβ-tubulin dimer via molecular dynamics simulations.

PloS one - 1 Jan 2012

Natarajan Kathiresan, Senapati Sanjib

Abstract excerpt

The vital role of tubulin dimer in cell division makes it an attractive drug target. Drugs that target tubulin showed significant clinical success in treating various cancers. However, the efficacy of these drugs is attenuated by the emergence of tubulin mutants that are unsusceptible to several classes of tubulin binding drugs. The molecular basis of drug resistance of the tubulin mutants is yet to be unraveled....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22879949
DOI: 10.1371/journal.pone.0042351
PMCID: PMC3413672

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