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Article

The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking.

eLife - 4 Sept 2018

Li Bo, Wong Chouin, Gao Shihong Max, Zhang Rulan, Sun Rongbo, Li Yulong, Song Yan

Abstract excerpt

The correct establishment and maintenance of unidirectional Notch signaling are critical for the homeostasis of various stem cell lineages. However, the molecular mechanisms that prevent cell-autonomous ectopic Notch signaling activation and deleterious cell fate decisions remain unclear. Here we show that the retromer complex directly and specifically regulates Notch receptor retrograde trafficking in Drosophila...

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Identifiers

PMID: 30176986
DOI: 10.7554/eLife.38181
PMCID: PMC6140715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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