Article
Jak3 deficiency blocks innate lymphoid cell development.
Mucosal immunology - 1 Jan 2018
Robinette M L, Cella M, Telliez J B, Ulland T K, Barrow A D, Capuder K, Gilfillan S, Lin L-L, Notarangelo L D, Colonna M
Abstract excerpt
Loss-of-function mutations in the tyrosine kinase JAK3 cause autosomal recessive severe combined immunodeficiency (SCID). Defects in this form of SCID are restricted to the immune system, which led to the development of immunosuppressive JAK inhibitors. We find that the B6.Cg-Nr1d1tm1Ven/LazJ mouse line purchased from Jackson Laboratories harbors a spontaneous mutation in Jak3, generating a SCID phenotype and an...
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