Article

Posttransplant B cell development and function in patients with B cell positive SCID caused by pathogenic variants in IL2RG and JAK3

2025-09-11

Abstract excerpt

<title>Abstract</title> <p> Genetic defects in <italic>IL2RG</italic> or <italic>JAK3</italic> can <italic/> cause the phenotype of severe combined immunodeficiency (SCID) with absent T- and non-functional B-lymphocytes (T-B+ SCID). B cell function and the need for immunoglobulin replacement after hematopoietic stem cell transplantation (HSCT) depends on the engraftment of donor B-lymphocytes. In a retrosp...

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Literature Corpus work: d04be65a-8d6d-5c58-ab42-52bd789ce808
DOI: 10.21203/rs.3.rs-7329087/v1

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