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Article

Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery.

Cell chemical biology - 21 Jul 2016

Wang Yuan, Cornett Allen, King Fred J, Mao Yi, Nigsch Florian, Paris C Gregory, McAllister Gregory, Jenkins Jeremy L

Abstract excerpt

The use of potent and selective chemical tools with well-defined targets can help elucidate biological processes driving phenotypes in phenotypic screens. However, identification of selective compounds en masse to create targeted screening sets is non-trivial. A systematic approach is needed to prioritize probes, which prevents the repeated use of published but unselective compounds. Here we performed a...

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PMID: 27427232
DOI: 10.1016/j.chembiol.2016.05.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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