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Article

Advantages and Challenges of Phenotypic Screens: The Identification of Two Novel Antifungal Geranylgeranyltransferase I Inhibitors.

Journal of biomolecular screening - 1 Mar 2016

Pries Verena, Cotesta Simona, Riedl Ralph, Aust Thomas, Schuierer Sven, Tao Jianshi, Filipuzzi Ireos, Hoepfner Dominic

Abstract excerpt

Phenotypic screens are effective starting points to identify compounds with desirable activities. To find novel antifungals, we conducted a phenotypic screen in Saccharomyces cerevisiae and identified two discrete scaffolds with good growth inhibitory characteristics. Lack of broad-spectrum activity against pathogenic fungi called for directed chemical compound optimization requiring knowledge of the molecular...

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PMID: 26459507
DOI: 10.1177/1087057115610488

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