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Article

Integrative genomic analysis implicates gain of PIK3CA at 3q26 and MYC at 8q24 in chronic lymphocytic leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2012

Brown Jennifer R, Hanna Megan, Tesar Bethany, Werner Lillian, Pochet Nathalie, Asara John M, Wang Yaoyu E, Dal Cin Paola, Fernandes Stacey M, Thompson Christina, Macconaill Laura, Wu Catherine J, Van de Peer Yves, Correll Mick, Regev Aviv, Neuberg Donna, Freedman Arnold S

Abstract excerpt

PURPOSE: The disease course of chronic lymphocytic leukemia (CLL) varies significantly within cytogenetic groups. We hypothesized that high-resolution genomic analysis of CLL would identify additional recurrent abnormalities associated with short time-to-first therapy (TTFT). EXPERIMENTAL DESIGN: We undertook high-resolution genomic analysis of 161 prospectively enrolled CLLs using Affymetrix 6.0 SNP arrays, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22623730
DOI: 10.1158/1078-0432.CCR-11-2342
PMCID: PMC3719990

Genes

MYC

Provenance

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