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Article

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

9 Feb 2012

Abstract excerpt

Although aberrant microRNA (miRNA) expression is linked to human diseases including cancer, the mechanisms that regulate the expression of each individual miRNA remain largely unknown. TAR DNA-binding protein-43 (TDP-43) is homologous to the heterogeneous nuclear ribonucleoproteins (hnRNPs), which are involved in RNA processing, and its abnormal cellular distribution is a key feature of amyotrophic lateral...

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PMID: 22323604
DOI: 10.1073/pnas.1112427109

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