Article
Update on recent molecular and genetic advances in frontotemporal lobar degeneration.
Journal of neuropathology and experimental neurology - 1 Jul 2008
Bigio Eileen H
Abstract excerpt
Great strides have been made in the last 2 years in the field of frontotemporal lobar degeneration (FTLD), particularly with respect to the genetics and molecular biology of FTLD with ubiquitinated inclusions. It is now clear that most cases of familial FTLD with ubiquitinated inclusions have mutations in the progranulin gene, located on chromosome 17. It is also clear that most ubiquitinated inclusions in FTLD...
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