Article
Deregulation of Plasma microRNA Expression in a TARDBP-ALS Family.
Biomolecules - 21 Apr 2023
Ruffo Paola, Catalano Stefania, La Bella Vincenzo, Conforti Francesca Luisa
Abstract excerpt
TDP-43 intracellular aggregates are a pathogenic sign of most amyotrophic lateral sclerosis (ALS) cases. Familial ALS, brought on by TARDBP gene mutations, emphasizes the relevance of this altered protein in pathophysiology. Growing evidence suggests a role for dysregulated microRNA (miRNA) in ALS disease. Furthermore, several studies showed that miRNAs are highly stable in various biological fluids (CSF, blood,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.