Article
Circulating Non-Coding RNA Levels Are Altered in Autosomal Dominant Frontotemporal Dementia.
International journal of molecular sciences - 25 Nov 2022
Fenoglio Chiara, Serpente Maria, Visconte Caterina, Arcaro Marina, Sorrentino Federica, D'Anca Marianna, Arighi Andrea, Rotondo Emanuela, Vimercati Roberto, Rossi Giacomina, Scarpini Elio, Galimberti Daniela
Abstract excerpt
Frontotemporal Dementia (FTD) represents a highly heritable neurodegenerative disorder. Most of the heritability is caused by autosomal dominant mutations in the Microtubule-Associated Protein Tau (MAPT), Progranulin (GRN), and the pathologic exanucleotide expansion of C9ORF72 genes. At the pathological level, either the tau or the TAR DNA-binding protein (TDP-43) account for almost all cases of FTD. Pathogenic...
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