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Article

Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study

6 Feb 2018

Abstract excerpt

OBJECTIVE: To determine whether exosomal microRNAs (miRNAs) in cerebrospinal fluid (CSF) of patients with frontotemporal dementia (FTD) can serve as diagnostic biomarkers, we assessed miRNA expression in the Genetic Frontotemporal Dementia Initiative (GENFI) cohort and in sporadic FTD. METHODS: GENFI participants were either carriers of a pathogenic mutation in progranulin, chromosome 9 open reading frame 72 or...

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PMID: 29434051
DOI: 10.1136/jnnp-2017-317492

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