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Article

FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Oct 2011

Rash Brian G, Lim H David, Breunig Joshua J, Vaccarino Flora M

Abstract excerpt

The processes regulating cortical surface area expansion during development and evolution are unknown. We show that loss of function of all fibroblast growth factor receptors (FgfRs) expressed at the earliest stages of cortical development causes severe deficits in surface area growth by embryonic day 12.5 (E12.5) in the mouse. In FgfR mutants, accelerated production of neurons led to severe loss of radial...

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Identifiers

PMID: 22031906
DOI: 10.1523/JNEUROSCI.4439-11.2011
PMCID: PMC3235689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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