Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emx2 patterns the neocortex by regulating FGF positional signaling.

Nature neuroscience - 1 Aug 2003

Fukuchi-Shimogori Tomomi, Grove Elizabeth A

Abstract excerpt

Molecular genetic studies implicate fibroblast growth factor 8 (FGF8), and the transcription factor Emx2, in development of the neocortical area map. Both are proposed to specify area position along the anterior-to-posterior axis of the cortical primordium. Whether FGF8 and Emx2 act independently or coordinately, or whether one controls the other, has not been determined. Here we report that Emx2, by regulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Mapping
Share to Electroporation
Share to Fibroblast Growth Factor 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factors

Share to Gene Transfer Techniques

Share to Mice, Inbred Strains

Share to Mice, Mutant Strains

Share to Neocortex

Source

Identifiers

PMID: 12872126
DOI: 10.1038/nn1093

Genes

FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emx2 patterns the neocortex by regulating FGF positional signaling.PMID 12872126Read ↗

Area patterning of the mammalian cortex.Semantic proximity Read ↗

Genetic regulation of arealization of the neocortex.Semantic proximity Read ↗

FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis.Semantic proximity Read ↗

Emx2 and Pax6 control regionalization of the pre-neuronogenic cortical primordium.Semantic proximity Read ↗

Cortical area size dictates performance at modality-specific behaviors.Semantic proximity Read ↗

Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding.Semantic proximity Read ↗

Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathologySemantic proximity Read ↗

Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex.Semantic proximity Read ↗

Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate.Semantic proximity Read ↗

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers.Semantic proximity Read ↗

Role of Emx2 in the development of the reciprocal connectivity between cortex and thalamus.Semantic proximity Read ↗

The lack of Emx2 causes impairment of Reelin signaling and defects of neuronal migration in the developing cerebral cortex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.