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Article

Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon.

Virology - 20 Dec 2011

Li Yi-Ping, Ramirez Santseharay, Gottwein Judith M, Bukh Jens

Abstract excerpt

The 5' untranslated region (5'UTR) of hepatitis C virus (HCV) is structured into four domains (I-IV) with numerous genotype-specific nucleotides. It is unknown whether the polymorphisms confer genotype-specific functions to the 5'UTR. Using viable JFH1-based Core-NS2 recombinants, we developed and characterized HCV genotypes 1-7 recombinants with highly diverse 5'UTRs (genotypes 1a and 3a), 2a recombinants...

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Identifiers

PMID: 22029937
DOI: 10.1016/j.virol.2011.10.002

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