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Article

Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α.

Gastroenterology - 1 Mar 2011

Scheel Troels K H, Gottwein Judith M, Mikkelsen Lotte S, Jensen Tanja B, Bukh Jens

Abstract excerpt

BACKGROUND & AIMS: Heterogeneity in the hepatitis C virus (HCV) protein NS5A influences its sensitivity to interferon-based therapy. Furthermore, NS5A is an important target for development of HCV-specific inhibitors. We aimed to develop recombinant infectious cell culture systems that express NS5A from isolates of the 7 major HCV genotypes, and determining their sensitivity to a specific NS5A inhibitor and to...

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PMID: 21111742
DOI: 10.1053/j.gastro.2010.11.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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