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Article

CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis.

Genes and immunity - 1 Sept 2004

Eri R, Jonsson J R, Pandeya N, Purdie D M, Clouston A D, Martin N, Duffy D, Powell E E, Fawcett J, Florin T H J, Radford-Smith G L

Abstract excerpt

CCR5 plays a key role in the distribution of CD45RO+ T cells and contributes to generation of a T helper 1 immune response. CCR5-Delta32 is a 32-bp deletion associated with significant reduction in cell surface expression of the receptor. We investigated the role of CCR5-Delta32 on susceptibility...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15215889
DOI: 10.1038/sj.gene.6364113

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15215889-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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