Article
CCR5-Delta32: implications in SLE development.
International journal of immunogenetics - 1 Jun 2014
Carvalho C, Calvisi S L, Leal B, Bettencourt A, Marinho A, Almeida I, Farinha F, Costa P P, Silva B M, Vasconcelos C
Abstract excerpt
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with strong genetic and environmental components. Previous studies have shown increased levels of several chemokines in active SLE. C-C chemokine receptor type 5 (CCR5) is involved in the recruitment of inflammatory cells into tissues, and mechanisms modulating CCR5 expression and function may interfere in SLE development, influencing the...
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