Article
Single nucleotide polymorphism of CC chemokine ligand 5 promoter gene in recipients may predict the risk of chronic graft-versus-host disease and its severity after allogeneic transplantation.
Transplantation - 15 Oct 2007
Kim Dong Hwan, Jung Hee Du, Lee Nan Young, Sohn Sang Kyun
Abstract excerpt
BACKGROUND: Leukocyte trafficking, regulated by chemokine ligands and their receptors, involves in the pathogenesis of graft-versus-host disease (GVHD) including CC ligand 5 (CCL5) or CC receptor 5 (CCR5). The current study analyzed the association of acute or chronic GVHD (cGVHD) with the CCR5/CCL5 gene single nucleotide polymorphisms (SNPs) of recipients and donors. METHODS: We evaluated the SNPs of CCL5...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.