Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.

doi:10.1038/346847a0

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Article

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.

Nature - 30 Aug 1990

Thomas K R, Capecchi M R

Abstract excerpt

The int-1 proto-oncogene was first identified as a gene activated in virally induced mouse mammary tumours. Expression studies, however, suggest that the normal function of this gene may be in spermatogenesis and in the development of the central nervous system. Genes sharing sequence similarity...

Topics

Animals
Blastocyst
Cell Line
Cerebellum
Chimera
DNA
Female
Genotype
Heterozygote
Homozygote
Male
Mesencephalon
Mice
Mice, Inbred C57BL
Motor Activity
Mutation
Nucleic Acid Hybridization
Proto-Oncogene Mas

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