Swaying is a mutant allele of the proto-oncogene Wnt-1.

doi:10.1016/0092-8674(91)90369-a

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Article

Swaying is a mutant allele of the proto-oncogene Wnt-1.

Cell - 29 Nov 1991

Thomas K R, Musci T S, Neumann P E, Capecchi M R

Abstract excerpt

Mice homozygous for the recessive mutation swaying (sw) are characterized by ataxia and hypertonia, attributed to the malformation of anterior regions of the cerebellum. We show that sw is a deletion of a single base pair from the proto-oncogene Wnt-1. The deletion is predicted to cause premature termination of translation, eliminating the carboxy-terminal half of the Wnt-1 protein. Histological examination shows...

Topics

Alleles
Amino Acid Sequence
Animals
Animals, Newborn
Base Sequence
Brain
Cloning, Molecular
Embryo, Mammalian
Genes, Recessive
Mice
Mice, Neurologic Mutants
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Insertional

Oligodeoxyribonucleotides

Proto-Oncogene Mas

Proto-Oncogene Proteins

Proto-Oncogenes

Wnt Proteins

Source

Open in PubMed

Identifiers

PMID: 1835670
DOI: 10.1016/0092-8674(91)90369-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1835670-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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