Article
A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice.
PloS one - 1 Jan 2011
Hughes Bryan G, Hekimi Siegfried
Abstract excerpt
Impairments of various aspects of mitochondrial function have been associated with increased lifespan in various model organisms ranging from Caenorhabditis elegans to mice. For example, disruption of the function of the 'Rieske' iron-sulfur protein (RISP) of complex III of the mitochondrial electron transport chain can result in increased lifespan in the nematode worm C. elegans. However, the mechanisms by which...
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