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Article

Ensemble-based computational approach discriminates functional activity of p53 cancer and rescue mutants.

PLoS computational biology - 1 Oct 2011

Demir Özlem, Baronio Roberta, Salehi Faezeh, Wassman Christopher D, Hall Linda, Hatfield G Wesley, Chamberlin Richard, Kaiser Peter, Lathrop Richard H, Amaro Rommie E

Abstract excerpt

The tumor suppressor protein p53 can lose its function upon single-point missense mutations in the core DNA-binding domain ("cancer mutants"). Activity can be restored by second-site suppressor mutations ("rescue mutants"). This paper relates the functional activity of p53 cancer and rescue mutants to their overall molecular dynamics (MD), without focusing on local structural details. A novel global measure of...

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Identifiers

PMID: 22028641
DOI: 10.1371/journal.pcbi.1002238
PMCID: PMC3197647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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