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Article

Molecular mechanisms of functional rescue mediated by P53 tumor suppressor mutations.

Biophysical chemistry - 1 Nov 2009

Tan Yu-Hong, Chen Y Morris, Ye Xiang, Lu Qiang, Tretyachenko-Ladokhina Vira, Yang Wei, Senear Donald F, Luo Ray

Abstract excerpt

We have utilized both molecular dynamics simulations and solution biophysical measurements to investigate the rescue mechanism of mutation N235K, which plays a key role in the recently identified global suppressor motif of K235/Y239/R240 in the human p53 DNA-binding domain (DBD). Previous genetic analysis indicates that N235K alone rescues five out of six destabilized cancer mutants. However, the solution...

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Identifiers

PMID: 19748724
DOI: 10.1016/j.bpc.2009.08.008
PMCID: PMC2794655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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