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Distinct Genetic and Epigenetic Signatures of Colorectal Cancers According to Ethnic Origin

1 Jan 2012

Abstract excerpt

BACKGROUND: The outcome of colorectal cancer varies depending on ethnic origin. Egyptian colorectal carcinoma is surprisingly young-age disease with high proportion of rectal and advanced stage cancers. METHODS: We characterized 69 sporadic Egyptian colorectal cancers for promoter methylation at 24 tumor suppressor genes, microsatellite instability, and expression of mismatch repair, p53, and β-catenin proteins....

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Share to Colorectal Cancer Screening and Detection
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

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PMID: 22028395
DOI: 10.1158/1055-9965.epi-11-0662

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