Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries.

doi:10.1158/1078-0432.CCR-05-1000

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Article

Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2005

Chan Annie O, Soliman Amr S, Zhang Qing, Rashid Asif, Bedeir Ahmed, Houlihan P Scott, Mokhtar Nadia, Al-Masri Nidal, Ozbek Ugur, Yaghan Rami, Kandilci Ayten, Omar Sherif, Kapran Yersu, Dizdaroglu Ferhunde, Bondy Melissa L, Amos Christopher I, Issa Jean-Pierre, Levin Bernard, Hamilton Stanley R

Abstract excerpt

PURPOSE: The epidemiology of colorectal carcinoma is well known to differ among countries but the molecular characteristics are usually assumed to be similar. International differences in molecular pathology have not been studied extensively but have implications for the management of patients in different countries and of immigrant patients. EXPERIMENTAL DESIGN: We evaluated the CpG island methylator phenotype...

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PMID: 16322286
DOI: 10.1158/1078-0432.CCR-05-1000

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