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Article

Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Natunen Teemu, Helisalmi Seppo, Vepsäläinen Saila, Sarajärvi Timo, Antikainen Leila, Mäkinen Petra, Herukka Sanna-Kaisa, Koivisto Anne Maria, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko

Abstract excerpt

Accumulation of amyloid β-peptide (Aβ) in the brain of Alzheimer's disease (AD) patients has been postulated to reflect defects in Aβ degradation or clearance. Here, we selected 12 genes (MMEL1, ECE1, ECE2, AGER, PLG, PLAT, NR1H3, MMP3, LRP1, TTR, NR1H2, and MMP9) involved in Aβ catabolism on the basis of PubMed-based literature search and elucidated their genetic role in AD among Finnish case-control cohort...

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Source

Identifiers

PMID: 22027013
DOI: 10.3233/JAD-2011-111109

Genes

TTR
AGER
ECE1
ECE2
LRP1
MMEL1
MMP3
MMP9
PLAT
PLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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