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Article

Rare Genetic Variants of the Transthyretin Gene Are Associated with Alzheimer's Disease in Han Chinese.

Molecular neurobiology - 1 Sept 2017

Xiang Qun, Bi Rui, Xu Min, Zhang Deng-Feng, Tan Liwen, Zhang Chen, Fang Yiru, Yao Yong-Gang

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent form of dementia in the world. The neuropathological characteristics of AD patients are the accumulation of extracellular plaques of β-amyloid (Aβ) and intracellular hyperphosphorylated tau protein. Transthyretin (TTR) may alleviate AD symptom by reducing Aβ concentration in the brain. There were reports for a decreased TTR level in both AD brain and blood. However,...

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Identifiers

PMID: 27562180
DOI: 10.1007/s12035-016-0065-2

Genes

TTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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