Article
A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly.
Molecular psychiatry - 1 Dec 2014
Chouraki V, De Bruijn R F A G, Chapuis J, Bis J C, Reitz C, Schraen S, Ibrahim-Verbaas C A, Grenier-Boley B, Delay C, Rogers R, Demiautte F, Mounier A, Fitzpatrick A L, Berr C, Dartigues J-F, Uitterlinden A G, Hofman A, Breteler M, Becker J T, Lathrop M, Schupf N, Alpérovitch A, Mayeux R, van Duijn C M, Buée L, Amouyel P, Lopez O L, Ikram M A, Tzourio C, Lambert J-C
Abstract excerpt
Amyloid beta (Aβ) peptides are the major components of senile plaques, one of the main pathological hallmarks of Alzheimer disease (AD). However, Aβ peptides' functions are not fully understood and seem to be highly pleiotropic. We hypothesized that plasma Aβ peptides concentrations could be a suitable endophenotype for a genome-wide association study (GWAS) designed to (i) identify novel genetic factors involved...
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