Article
Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosamine.
Antimicrobial agents and chemotherapy - 1 Jan 2012
Henry Rebekah, Vithanage Nuwan, Harrison Paul, Seemann Torsten, Coutts Scott, Moffatt Jennifer H, Nation Roger L, Li Jian, Harper Marina, Adler Ben, Boyce John D
Abstract excerpt
We recently demonstrated that colistin resistance in Acinetobacter baumannii can result from mutational inactivation of genes essential for lipid A biosynthesis (Moffatt JH, et al., Antimicrob. Agents Chemother. 54:4971-4977). Consequently, strains harboring these mutations are unable to produce the major Gram-negative bacterial surface component, lipopolysaccharide (LPS). To understand how A. baumannii...
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