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Article

ISAba1-dependent overexpression of eptA in clinical strains of Acinetobacter baumannii resistant to colistin

14 May 2019

Abstract excerpt

BACKGROUND: Colistin resistance in Acinetobacter baumannii often results from mutational activation of the two-component system PmrAB and subsequent addition of phospho-ethanolamine (pEtN) to lipooligosaccharide by up-regulated pEtN transferase PmrC. OBJECTIVES: To characterize mechanisms of colistin resistance independent of PmrCAB in A. baumannii. METHODS: Twenty-seven colistin-resistant A. baumannii were...

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PMID: 31199431
DOI: 10.1093/jac/dkz241

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