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Article

Phenotypic changes associated with Colistin resistance due to Lipopolysaccharide loss in Acinetobacter baumannii.

Virulence - 31 Dec 2018

Carretero-Ledesma Marta, García-Quintanilla Meritxell, Martín-Peña Reyes, Pulido Marina R, Pachón Jerónimo, McConnell Michael J

Abstract excerpt

Acinetobacter baumannii can acquire resistance to colistin via complete loss of lipopolysaccharide (LPS) biosynthesis due to mutations in the lpxA, lpxC and lpxD genes. However, although colistin is increasingly being used for the treatment of multidrug resistant infections, very few A. baumannii clinical isolates develop colistin resistance through loss of LPS biosynthesis. This may suggest that LPS loss affects...

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Identifiers

PMID: 29638177
DOI: 10.1080/21505594.2018.1460187
PMCID: PMC5955468

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TNF

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Phenotypic changes associated with Colistin resistance due to Lipopolysaccharide loss in Acinetobacter baumannii.PMID 29638177Read ↗

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Colistin Resistance Mechanism and Management Strategies of Colistin-Resistant <em>Acinetobacter baumannii</em> InfectionsSemantic proximity Read ↗

Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosamine.Semantic proximity Read ↗

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