Article
Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice.
PloS one - 1 Jan 2011
Bühling Frank, Kouadio Martin, Chwieralski Caroline E, Kern Ursula, Hohlfeld Jens M, Klemm Nicole, Friedrichs Nicole, Roth Wera, Deussing Jan M, Peters Christoph, Reinheckel Thomas
Abstract excerpt
BACKGROUND: The 11 human cysteine cathepsins are proteases mainly located in the endolysosomal compartment of all cells and within the exocytosis pathways of some secretory cell types. Cathepsin H (Ctsh) has amino- and endopeptidase activities. In vitro studies have demonstrated Ctsh involvement in the processing and secretion of the pulmonary surfactant protein B (SP-B). Furthermore, Ctsh is highly expressed in...
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